RT-PCR experiments shed light on the molecular mechanisms by which GHRP-6 appeared to modulate the fibrotic response. Among the genes studied (Table 1), GHRP-6 proved to significantly reduce TGFB1 and CTGF () expression, with no effect on PDGFB gene expression. An unexpected finding was that MMP3 appeared significantly reduced in the GHRP-6-treated wounds (). Most meaningfully is that PPARG expression became significantly elevated with GHRP-6 treatment (), as compared to placebo-treated wounds (Figure 7).
As the name indicates, this peptide is a fragment of human growth hormone. It is more specifically a modified form of the amino acids 176-191 in the C-terminal section of the latter substance. Bodybuilders mainly use it enhance fat burning for improved and more noticeable muscle growth. For weight loss, HGH Fragment 176-191 is thought to be considerably more potent than regular growth hormone. It also offers anti-aging benefits as a result of positive effects on IGF-1 levels.
Among the other reasons why bodybuilders use peptides is its ability to help you recover faster. They assist in making oxygen available to the muscle cells in sufficient amount. They also improve user’s level of endurance. These benefits make them popular among athletes generally. Peptides further help to burn body fat, which is another reason they are considered beneficial in bodybuilding.
GHRH/GHRP-6 was the first of a family of synthetic peptides that enhance the release of the GH by the pituitary gland in a dose-dependent manner. Since its discovery, it has been used as a benchmark and starting point for many of the research aims to obtain new drugs, but none of its implications are more engaging than the treating of the obesity epidemic.
Ghrelin has many activities in the body besides stimulating GH release. It stimulates appetite, is cardioprotective, can help protect cells against oxidative damage, can reduce inflammation and promote healing, and can promote fat-burning in muscle. There is also some effect on increase in cortisol production via increase in ACTH, and increase in prolactin. However, where the activity of ghrelin is comparable to that which ordinarily occurs during fasting, effects on cortisol and prolactin likewise are comparably only to that experienced while fasting.
So… now we get down to the individual peptides themselves. I will not go into length with a profile for each one, but instead I will provide two charts that should help in understanding which peptides are GHRH’s and which ones are GHRP’s. Of course, IGF and MGF have their own respective spots but do not have the synergy when combined like GHRP and GHRH.
Bottom line, more growth hormone in your system, regardless of where it came from, dramatically improves the way your entire body looks at the beach. It used to be used to treat dwarfism, but in 1990 researchers wondered what would happen in normal guys which spawned a study in The New England Journal of Medicine which found when men over 60 years old took GH for six months they gained on average 8.8% lean body mass and lost 14% fat mass – predominately around the waist – increased their skin thickness (your skin is thicker and more elastic when you’re young), increased their bone density by 1.4% and felt a greater sense of well-being. Not a bad effort, but more GH in your system, courtesy of GHRP6, also impacts your appetite in the fiercest way possible. Roughly 20-30 minutes after injecting it you’ll get an intense surge in the desire to dent the contents of your fridge. That’s because GHRP-6 riles up the peptide ghrelin, which tells your stomach to empty its contents and signal man-sized hunger burst. If you’re taking high doses, the growling bear inside your gut can cause you to feast uncontrollably; great if you’re trying to add muscle, less than ideal if you’re trying to strip fat. To skirt around this, timing can be crucial, with many users taking a dose directly after a workout. This allows them to slam their post workout protein shake then a short while later, lock into a feast of epic proportions that’ll trigger muscle growth. If you’re trying to lose fat, the simple fix is to lower your dose slightly, the site ResearchPeptides.com recommends limiting your intake to no more than 150 micrograms. So if you going to use it then supplement smart and tailor your doses to your goals.