During the last 15 years, a plethora of experimental evidence supports the pharmacological benefits of the exogenous administration of synthetic growth hormone-releasing peptides (GHRPs). In parallel to their growth hormone-releasing action, these agents exert cytoprotective effects encompassing cardiac and extracardiac organs . GHRP-6 is a class of peptidyl GH secretagogue, similar to met-enkephalin, that has reproducibly shown antinecrogenic and antiapoptotic properties in multiple experimental scenarios, including ischemia/reperfusion [9–11]. Globally speaking, exogenously administered GHRP-6 has broadly been shown to act as a prosurvival factor for cells and tissues threatened by otherwise lethal insults.
But ever since the 1970’s, scientists have observed that although we produce substantial amounts of both IGF-1 and human growth hormone (HGH) in childhood, these hormones decrease drastically by the time we reach old age. They also noticed that IGF-1 could possibly be manipulated to extend life and to prolong the deteriorating effects of aging (you can read the research here).
As with any GHRP or GHRH, administration of GHRP-6 doses should be done no sooner than 2 hours following the last meal containing carbohydrates or fats, and no sooner than 30 minutes prior to the next consumption of carbohydrates or fats. As evidenced by studies referenced in the introduction of this profile, the consumption of fats and carbohydrates will significantly blunt (but not eliminate) HGH release. HGH pulses will generally reach their peak by about 30 minutes following injection, after which it is then acceptable to consume a meal containing carbohydrates and fats.
Hypertrophic scarring is a form of abnormal, exuberant healing, locally aggressive, and recurrent cutaneous fibroproliferative condition, characterized by excessive extracellular matrix (ECM) accumulation during the cutaneous healing process. Including keloids and hypertrophic scars (HTS), these aberrant processes lead to esthetically disfiguring scars, patients’ psychological stress, and functional impairment . The cellular and molecular mechanisms underlying the formation of these raised dermal scars are poorly understood. Recent whole genome profiling and proteomic studies have led to the identification of regulatory elements with different expression profiles in HTS and keloid tissues . The limited understanding of the pathophysiology of these processes has led to investigating a broad spectrum of potential antihypertrophic scarring candidates .
It is here that Growth Hormone Releasing Peptide 6, or Growth Hormone Releasing Hexapeptide comes into the picture. Also called as GHRP-6, it is a synthetic met-enkephalin analog. It includes unnatural D amino acids. It is instrumental in releasing growth hormone that helps in muscle recovery, strengthing of joints and tendons, and fat loss. It is distinct from Growth Hormone Releasing Hormone or GHRH which causes a higher amount of growth hormone to be secreted during the body normal secretion time. GHRP-6 on the other time will target a pulse and force the pituitary to release the growth hormone that is stored there. It helps a particular muscle group to achieve maximum growth.
Tβ4 has been used at our clinic with a great deal of success in patients suffering from Lyme disease or other infectious and/or inflammatory conditions. Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable drug.
Ghrelin has many activities in the body besides stimulating GH release. It stimulates appetite, is cardioprotective, can help protect cells against oxidative damage, can reduce inflammation and promote healing, and can promote fat-burning in muscle. There is also some effect on increase in cortisol production via increase in ACTH, and increase in prolactin. However, where the activity of ghrelin is comparable to that which ordinarily occurs during fasting, effects on cortisol and prolactin likewise are comparably only to that experienced while fasting.
As a athlete, incorporating a growth hormone-like Ipamorelin is extremely beneficial. Not only in the development of lean muscle tissue and muscle mass, but also in the decreased recovery time you are going to experience after each workout. You can workout more, you can workout and lift harder, and you can increase your level of exertion at the gym to experience the greatest gains, as your body is going to heal much faster than it would without the growth hormone.
In no particular order of importance, here they are: I swallow colostrum capsules every morning, I drink raw animal milk such as camel milk and goat milk in moderation, and I use the equivalent of around 30 grams of grass-fed whey protein each day in a smoothie (if you’re vegan or if whey protein doesn’t agree with your stomach, you can combine digestive enzymes with a vegan protein such as brown rice protein, pea protein or hemp protein for an effect similar to whey protein).
High testosterone at this stage will accelerate the process. The SARMs are not testosterone, and don’t get metabolised into DHT (nor estradiol). The SARMs selectively bind to the androgen receptor in muscle and bone and amplify the effect of testosterone and DHT there, while not amplifying the effect on other tissue ie skin, prostate. However, through inheritance, if you have hair androgen receptors that are similar to muscle/bone androgen receptors, then SARMs can amplify the androgen message in the hair follicles, and if the inherited androgen sensitivity is activated, it could lead to accelerated male pattern baldness. This is a very rare variation, and while possible, is uncommon. There are no tests available to determine SARMs effect on your hair follicles, nor to determine when your genetic androgen sensitivity in hair follicles will activate.
You’re no doubt taking it for the fairy tale positive side effects, which have already been outlined, but like any caper about something enchanted, the magic comes with a price. For GHRP6 these can include flu-like symptoms, joint aches, headaches and water retention. Prolonged use can give you a tingling feeling in your skin than can also lead to a loss of sensitivity to touch. Yeah, you don’t want it down there. Fortunately, this is often in rare cases and when you consider even garden-variety paracetamol can dish out hives, diarrhoea and nausea then by comparison these aren’t huge risk factors. The biggest drawback is that it has a meagre half-life of 15-60 minutes, which means you have to take it daily for it to be effective, with the primary method of administration being a big ole fat needle. So the idea of turning the glutes into something that resembles nanna’s pincushion may deter pretty much all-conscientious pain objectors.