Drug discovery is an uncertain ground in which disappointments and rewards are encountered. Most of those who have been involved in GHRP research have enjoyed clear-cut data, which in most of the cases are all in with very few outs. Exceptionally, a pharmacologically active agent appears to be endowed with such a variety of useful properties as to make it highly drugable. The fact that synthetic GHRPs bind at least two different and biologically significant receptors that seem not to be redundant in nature and are largely represented in most organs and tissues broadens their biological activities and increases their pharmacological potentialities. This suggests that GHRPs may stimulate multiple cells and simultaneously trigger different signaling pathways. The information gathered so far in terms of the molecular cytoprotective mechanism of GHRPs is inconclusive and fragmentary, which has become difficult to disclose the hidden facts behind their biological effects. Nevertheless, it is reasonable that these molecules share the ability to knock life-sensitive pathways and restore critical organelle physiology at very proximal levels. Beyond their ability to enhance the survival of a diversity of cells and tissues before adverse episodes, GHRP members exert an agonistic effect of the GH/IGF-1 axis, promoting anabolia and deterring catabolism and sarcopenia.

CJC-1295 is also known by the names of Modified GRF 1-29, Mod GRF 1-29, CJC-1295 without DAC (DAC stands for Drug Affinity Complex) and also by its chemical name tetrasubstituted GRF (1-29). This variety of names makes it difficult for the average consumer to select or even research upon this compound. Since some manufacturers list all of its names and others list only one, it also becomes very confusing. However, there is a reason for this wide variety of names.
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Adults do not stop producing growth hormone as they get older; in fact, it's a myth that's spread by the HRT/TRT industry. However, as you get older, it's harder to activate the body’s release or pulse of growth hormone as frequently as you did when you were still growing; hence, the term “when I was younger...”. Who doesn't remember how great they felt at 18, versus 38!

IGF-1 also increases the activity of muscle protein synthesis and the activity of muscle stem cells (also called satellite cells) for repair of damaged muscle. This is probably why intense weight training is one primary stimulus for a natural release of IGF-1 in muscle. As a matter of fact, exercise researchers have found that systemic IGF-1 normally produced in the liver isn’t even required for this type of muscle repair, as other IGF-1 forms produced by your own muscles during and post-exercise allows for adequate muscle tissue repair.
The increase in GH secretion due to IPAMORELIN (and other GHRP) leads to an increase in IGF-1 (thought to be the anabolic mechanism of GH).  As we get older GH and subsequently IGF-1 decrease substantially.  This decline is thought to be one of the major causes of the ageing process.  By increasing these levels again there is increased collagen synthesis, promotion of lean muscle mass, bone strength, improved healing capability, improved sleep cycle, increased energy, repair and regeneration of internal organs, strengthening of joints/cartilage/connective tissue, and anti ageing effects on the skin. 

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Abbreviations: AKT1, RAC-alpha serine/threonine-protein kinase; AMI, acute myocardial infarction; CTGF, connective tissue growth factor; DCM, dilated cardiomyopathy; dP/dt, the rate of left ventricle maximal pressure rise in early systole; DX, doxorubicin; ECM, extracellular matrix; EGF, epidermal growth factor; ERK1/2, extracellular signal-regulated kinase 1/2; GH, growth hormone; GHRH, growth hormone-releasing hormone; GHRPs, growth hormone-releasing peptides; GHS, growth hormone secretagogues; GHS-R, growth hormone secretagogue receptor; GHS-R1a, growth hormone secretagogue receptor type 1a; HIF-1α, hypoxia-inducible factor-1 alpha; I/R, ischemia and reperfusion; IGF-1, insulin-like growth factor-1; IL-1β, interleukin-1 beta; IL-6, interleukin 6; LPS, lipopolysaccharide; LV, left ventricle; LVEF, left ventricular ejection fraction; MBP, mean blood pressure; MIF, macrophage migration inhibitory factor; MCP-1, monocyte chemoattractant protein-1; MMP, matrix metalloproteinase; MOD, Multiple Organs Damage; NEP, nitrosylation end products; NIH, National Institute of Health; PDGF, platelet-derived growth factor; PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1 alpha; PI-3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; PPARγ, peroxisome proliferator-activated receptor gamma; RAS, rennin–angiotensin system; rhGH, recombinant human growth hormone; ROS, reactive oxygen species; TGF-β, transforming growth factor beta; TIMP, tissue inhibitor of metalloproteinase; TNF-α, tumor necrosis factor alpha.
One common concern when it comes to GHRP-6 doses (or the doses of any Ghrelin mimetic/GHRP) is the fact that it has been found to exhibit the ability to induce secretion of Cortisol and Prolactin. While many studies have indeed demonstrated this[5], they have also demonstrated that the Prolactin and Cortisol increases in most test subjects were not altered at all at GHRP-6 doses of 100mcg or less[6] [7]. GHRP-6 doses that are increased above 100mcg will exhibit increased Cortisol and Prolactin secretion, but minimally. As the dose is further increased, it stands to reason that the Cortisol and Prolactin secretions will increase as well.
But gene-therapy experiments have also resulted in patient deaths. The use of such therapies can cause the human body to experience fatal immune reactions to the vectors used to place the gene in the body. Another danger of gene therapy is an inability to control the expression of the gene, which could translate into a rapidly spreading cancer. Or the expression of the gene could spread from skeletal muscle into heart muscle, resulting in excessive heart muscle growth (known as left ventricular hypertrophy, or “athlete’s heart) that can cause premature heart failure.
GH’s big USP is its ability to overcome injuries thanks to its restorative properties. Sadly, this notion is still in the firmly in the journal of bro-science. Research in the Clinical Science found when pigs were injected daily with GHRP-6 it had powerful antioxidant effects that could reduce internal heart attack damage. Your DNA isn’t bacon, but it does offer the telltale signs of a potential healing agent and many lifters do report success with restoring long-term overuse injuries, such as tendinitis or rotator cuff niggles. So while beefed up singlet-wearers have sung its praise, the labcoat-wearers haven’t confirmed its scientific efficacy just yet. So watch this space for the new GHRP-6 science that could keep your physique in the sweat game.
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