CJC-1295 is a fast-acting Growth Hormone Releasing Hormone designed to enhance the body’s natural production and release of human growth hormone and Insulin-like Growth Factor 1 (IGF-1). In doing so, CJC-1295 reverses the age-related decline, generates new muscle cells and increases fat loss. Another great trait of CJC-1295 is its ability to promote slow wave sleep, a deep sleep responsible for the highest levels of cell regeneration, muscle growth and memory retention.

CJC-1295 increases the production of growth hormone as well as IGF-1 – which has anabolic effects in adults. However, it does not increase the levels of prolactin – high levels of which can create impotence and mental health problems in men. By increasing these two hormones, it enhances protein production in the body, which in turn, boosts muscle mass. It also induces lipolysis – the breakdown of fat tissue, boosts recovery from injuries, increases bone density, and also reduces aging factors like skin wrinkles. It can also stimulate cell growth, due to which it can be used to treat withered tissue or organs.


Boasting similar structure as CJC-1295, sermorelin is commonly used for anti-aging purposes. But it is also considered useful for muscle building. It accounts for 29 amino acids of the 44 that make up growth hormone releasing hormones. This peptide is very potent for improving HGH levels, as shown in studies. It was observed that the 1-29 amino acid chain is mainly responsible for the ability of GHRH to stimulate release of growth hormone by the pituitary. However, sermorelin has very short half-life of about 10 minutes or less.
If you’re looking to increase your muscle growth and improve strength, whether for competitive bodybuilding or to achieve a personal physique goal, our Australian muscle building peptide supplements can help. Our dedicated research and product development team have consistently produced new products that perform better than other supplement brands, so you know you’ll be getting the best peptide supplements available. If you’re new to peptide supplements and have questions, read our FAQ’s, or alternatively email us at info@musclepeptidesaustralia.com.au and our clinic doctor can help you with your questions.
It should be noted right off the bat that GHRP-6 doses are often normally (and ideally) combined with doses of a GHRH analogue, such as Mod GRF 1-29 (CJC-1295 without DAC) due to the synergistic effects and compatibility between the two, as previously mentioned in this profile. With that being said, the proper GHRP-6 doses do not change whether or not it is utilized with a GHRH. If an effective GHRP-6 dose is 100mcg, for example, then 100mcg of GHRP-6 should be administered whether the user is utilizing it alone or with Mod GRF 1-29. The term/phrase “saturation dose” or “saturation doses” can be heard a lot when peptides are discussed. A saturation dose is defined as a dose that will completely (or near completely) saturate the peptide’s target receptors. In GHRP-6’s case, this means the Ghrelin receptors located on the hypothalamus and the anterior pituitary.

Our hormone levels decline as we age, and therefore the effects of these hormones decline proportionally. Even if you exercise and eat well, you will still experience this decline in hormone production and all of the associated adverse health effects that this brings. To fight ageing, and increase vitality, we can restore our hormones to their youthful levels.
Basic molecular pathophysiological cascade of acute myocardial infarction. Hypoxia triggers an acute failure in mitochondrial respiratory function when the diffusible oxygen stores become exhausted. Adenosine triphosphate reserves are rapidly depleted, and there is a respiratory shift toward an anaerobic profile. Lactate, H+ ions, CO2, and potassium accumulate may lead to arrhythmias, microendothelial damage, myocardiocytes stunning, and cell death. Adenosine triphosphate (ATP) depletion is irrevocably ligated to the inability of maintaining the normal negative resting membrane potential, to an alteration of calcium homeostasis (intracellular Ca2+ ([Ca2+]i) overload), which may eventually lead to different patterns of abnormal cardiac contraction. Mitochondrial functionality becomes abnormal, establishing the so-called “open pore” (mitochondrial permeability transition pore [mPTP]), leading to local cell death. In this scenario, mitochondria turn into an active ROS manufacturing plant that increases and perpetuates mitochondrial damages and dysfunction. The failure of myocardial contractility (contractility depression) is a precocious and multifactorial consequence of ischemia, which may eventually lead to reduced cardiac output and heart failure. This situation may translate into a self-perpetuated vicious circle, thus amplifying the ischemic episode and the myocardial wall stress. The local inflammatory reaction is a useful but critical operator within the myocardial ischemia/reperfusion damage process. Hypoxia itself activates the HIF-α/MIF axis and the consequent downstream inflammatory cascade. The locally secreted pro-inflammatory cytokines are involved in a self-perpetuating process in the ROS chain reaction, inflammation, and cellular damage.

In June 2010, the National Drugs and Poisons Schedule Committee (NDPSC) considered the scheduling of paracetamol in combination with ibuprofen. Paracetamol preparations containing 500 mg or less of paracetamol as the only therapeutically active constituent (other than phenylephrine, effervescent agents or guaiphenesin) in packs of 25 or less were exempt from scheduling. However, when these preparations were combined with another therapeutically active ingredient they became Schedule 2. The NDPSC considered that the Schedule 2 entry remained appropriate, but noted the possibility that more robust evidence of additional risk could come to light through any application for product approval with the Therapeutic Goods Administration. The delegate confirmed the NDPSC's decision and the reasons for the decision in August 2010.
It’s a man… it’s a plane… it’s a man eating a cactus! Not all heroes wear capes. To a superhero, secrecy is their most important power. Everyone from Bruce Wayne to Peter Parker can tell you this. Though, no matter how much you try to hide it, sometimes your character starts to slip out. Normal life can be hard; a friendly dinner can cause cravings for cactus, while running out of gas can turn into a truck-pulling contest. Not all heroes wear capes and most can’t help but save the world… one drumroll at a time. Credit: Various via Storyful
The known side effects of IGF-1 injections include jaw pain, facial and hand swelling and heart-rhythm disturbances, especially if doses of more than 100 micrograms (mcg) are injected. Exceeding 100mcg of IGF-1 can actually cause your heart to stop beating and blood pressure to drop dramatically. This is caused by an IGF-1-induced drop in blood phosphate levels, and in the bodybuilding community is often prevented by administering phosphate with the IGF-1.
Peptides offer a number of health benefits and bodybuilding is a field where these peptides are useful as well. When it comes to bodybuilding and sports performance, peptides help increase number of muscle cells. They even help to reverse the generic outlook along with allowing you to increase the muscle density. Use of peptides simply means that you will be able to develop muscle density you dream of.

These studies on human subjects were paralleled by contemporary experimental progresses in basic science, which demonstrated that hexarelin enhanced H9c2 cardiomyocyte proliferation in a dose-dependent manner. Since these were in vitro experiments, they completely excluded a potential intervention of the GH axis and clearly indicated a direct GHRP binding to cardiac cells membranes.32 Weekers et al33 demonstrated that 14 days of pretreatment with GHRP-2, but not GH, selectively protected against the postischemic diastolic dysfunction and myocardial stunning of excised hearts submitted to ischemia/reperfusion in isolated, perfused rabbit hearts.
Taking into account the broad spectrum of TGF-β1 physiology in the fibroblasts/myofibroblasts differentiation events [33], we deem that the reduction of the local scar cellularity and perichondrial matrix accumulation in those animals receiving GHRP-6 could be attributable to TGFB1 transcriptional and functional switch-off. Since the predominant microscopic aspect of the GHRP-6-treated wounds was characterized by meagre cartilage scars, slimmer perichondrium membranes, and far less active cells, we hypothesize that the peptide somehow attenuates the perichondrial activation response to the trauma and/or a possible mesenchyme-to-mesenchyme redifferentiation process, thus lessening the surge of fibroblast and myofibroblasts. In line with this notion, we had documented that GHRP6 prevented hepatic stellate cells activation by reducing CD68, α-SMA, and vimentin local expressions. All these events could be primarily presided by the GHRP-6-related reduction of TGFB1 and CTGF expression in both parenchymal and nonparenchymal cells [7].
Basic molecular pathophysiological cascade of acute myocardial infarction. Hypoxia triggers an acute failure in mitochondrial respiratory function when the diffusible oxygen stores become exhausted. Adenosine triphosphate reserves are rapidly depleted, and there is a respiratory shift toward an anaerobic profile. Lactate, H+ ions, CO2, and potassium accumulate may lead to arrhythmias, microendothelial damage, myocardiocytes stunning, and cell death. Adenosine triphosphate (ATP) depletion is irrevocably ligated to the inability of maintaining the normal negative resting membrane potential, to an alteration of calcium homeostasis (intracellular Ca2+ ([Ca2+]i) overload), which may eventually lead to different patterns of abnormal cardiac contraction. Mitochondrial functionality becomes abnormal, establishing the so-called “open pore” (mitochondrial permeability transition pore [mPTP]), leading to local cell death. In this scenario, mitochondria turn into an active ROS manufacturing plant that increases and perpetuates mitochondrial damages and dysfunction. The failure of myocardial contractility (contractility depression) is a precocious and multifactorial consequence of ischemia, which may eventually lead to reduced cardiac output and heart failure. This situation may translate into a self-perpetuated vicious circle, thus amplifying the ischemic episode and the myocardial wall stress. The local inflammatory reaction is a useful but critical operator within the myocardial ischemia/reperfusion damage process. Hypoxia itself activates the HIF-α/MIF axis and the consequent downstream inflammatory cascade. The locally secreted pro-inflammatory cytokines are involved in a self-perpetuating process in the ROS chain reaction, inflammation, and cellular damage.
Ghrelin has many activities in the body besides stimulating GH release. It stimulates appetite, is cardioprotective, can help protect cells against oxidative damage, can reduce inflammation and promote healing, and can promote fat-burning in muscle. There is also some effect on increase in cortisol production via increase in ACTH, and increase in prolactin. However, where the activity of ghrelin is comparable to that which ordinarily occurs during fasting, effects on cortisol and prolactin likewise are comparably only to that experienced while fasting.
In October 2005, the NDPSC decided to amend the Schedule 5 entry for thyme oil to include the wording "in medicines for human therapeutic use, when packed in containers having a nominal capacity of 25 mL or less fitted with a restricted flow insert and when the label on the primary pack complies with the requirements of the Required Advisory Statements for Medicine Labels".
Thanks to the assiduousness of talented researchers around the globe, our contemporary understanding of the pharmacology and probably also the physiological regulation of growth hormone secretion, came about after the important discovery that GHRP increased pulsatile GH secretion in not only children, but also within normal younger and older men and women. Even though GHRP alone substantially releases GH from the pituitary in vitro without the addition of GHRH, this rhythmic endogenous secretion does require some GHRH.
Ghrelin has many activities in the body besides stimulating GH release. It stimulates appetite, is cardioprotective, can help protect cells against oxidative damage, can reduce inflammation and promote healing, and can promote fat-burning in muscle. There is also some effect on increase in cortisol production via increase in ACTH, and increase in prolactin. However, where the activity of ghrelin is comparable to that which ordinarily occurs during fasting, effects on cortisol and prolactin likewise are comparably only to that experienced while fasting.
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There is evidence of involvement of organised crime in supply of the substances. The substances are offered for sale via the internet. Many of the substances are promoted as safe alternatives to traditional performance enhancing substances such as the anabolic steroids. Suppliers are making unproven assertions about the efficacy and safety of the substances.

The original GRF (1-29) has a half-life of about 30 minutes. Half-life means the time within which half of the hormone administered will be destroyed within the body. This short half-life is due to the fact that the compound is highly unstable and breaks down soon. To increase its stability and to make it last longer, it was modified by adding 4 amino acids in its structure. This gave it the name Modified GRF (1-29) or Mod GRF 1-29. It was originally invented by DatBtrue. The portion of the molecule that actually stimulates the growth hormone secretion is found in the chain of 29 amino acids, so it is named GRF (1-29). This chemical also produces slow-wave sleep.
The delegates have decided to accept the advice of the expert advisory committees that the current scheduling of preparations in Schedules 5 and 6 remains appropriate. The delegates noted the decision to retain listing of teeth whitening preparations containing up to 6 per cent hydrogen peroxide or 18 per cent carbamide peroxide in Schedule 5, or exempt when below 3 per cent and 9 per cent respectively, is to some extent also consistent with the evaluation of such products by the European Commission Scientific Committee on Cosmetics and Non Food Products intended for Consumers (SCCNFP).
One of the other uses for GHRP-6 is to kick start your own GH after a cycle, a dose of 200-500mcg 2x a day is sufficient to start your own GH; however, it does not mean your own GH levels will be where they were before you carried out your cycle, this is user dependent. It will certainly be a very useful addition to any hormonal cycles' PCT, as the increased IGF-1 levels it brings will greatly increase the chances of you holding on to any muscle you have gained.
GHRH/GHRP-6 was the first of a family of synthetic peptides that enhance the release of the GH by the pituitary gland in a dose-dependent manner. Since its discovery, it has been used as a benchmark and starting point for many of the research aims to obtain new drugs, but none of its implications are more engaging than the treating of the obesity epidemic.
The conclusion comes down to which peptides should you use. This is going to depend on personal use and experience. Whether you are into bodybuilding, gaining an edge in sports or just looking for health and wellness and anti aging properties, peptides offer a little something for everyone. There are many peptides that are not covered below, but as an introduction into the peptide world these are the most generic and widely used. As with any supplement or drug, please do your own research before diving into using peptides.

Thymosin alpha-1 (T α 1) is a peptide, or small protein, consisting of 28 amino acids. T α 1 is produced naturally by the thymus gland. The thymus is located behind the sternum and between the lungs, and is where immune cells known as T cells mature and are released, prompted to do so by the T α 1 peptide. T cell production and action within the body is vital to adaptive immunity—the mode by which immune cells are able to recognize and eradicate foreign invaders.


As with any GHRP or GHRH, administration of GHRP-6 doses should be done no sooner than 2 hours following the last meal containing carbohydrates or fats, and no sooner than 30 minutes prior to the next consumption of carbohydrates or fats. As evidenced by studies referenced in the introduction of this profile, the consumption of fats and carbohydrates will significantly blunt (but not eliminate) HGH release. HGH pulses will generally reach their peak by about 30 minutes following injection, after which it is then acceptable to consume a meal containing carbohydrates and fats.
In June 2003, the NDPSC decided to reschedule mometasone from Schedule 3 to Schedule 2 for the short-term prophylaxis or treatment of allergic rhinitis, with dose and age restrictions. The NDPSC considered that this rescheduling was appropriate given mometason's extensive local and overseas experience, demonstrated effectiveness in the treatment of allergic rhinitis and that allergic rhinitis is readily diagnosed and self-monitored by the consumer with pharmacist advice or counselling available if necessary. As there would no longer be a Schedule 3 entry, the NDPSC also decided to delete mometasone from Appendix H.
to amend the Standard for the Uniform Scheduling of Medicines and Poisons to include vitamin D, as a single weekly dose of up to 175 micrograms (7000IU) per recommended dose, in Schedule 3 (noting that the wording "per recommended weekly dose" in the interim decision's proposed Schedule 3 entry should have read "per recommended single weekly dose"); and
Triamcinolone acetonide (TA) has long been the steroid of choice for the treatment of skin fibrotic disorders, providing the best relief of local symptoms such as scars flattening. Nevertheless, TA is associated with adverse events such as dermal atrophy, telangiectasia, and immunosuppression [4, 5]. Despite the multitude of therapeutic strategies to prevent or reduce keloid and HTS formation, these conditions remain as orphan clinical niches of ultimately effective interventions [6].
I have not used IGF-1 but I have used a stack of Ipamorelin and CJC 1295 no DAC. I did not do any lab tests before, during or after but definitely noticed increased fat loss and better sleep. I was not trying to increase muscle so there was no change to speak of for me. But you are not recommending their use even without IGF-1, is that correct? I do not compete in anything so WADA is not a concern.
Various experiments have been conducted to test the effectiveness of CJC 1295-DAC in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection. Mean half-life was shown to be 5.8-8.1 days, also after multiple doses mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported in any group.
CJC-1295 is basically a peptide hormone that acts similar to growth hormone releasing hormones (GHRH). Invented by a Canadian biotechnology company called ConjuChem, it is beneficial to athletes because it can bioconjugate with circulating albumin and increase the time it can be used for medical purposes. It achieves this by preventing degradation of its amino acids. With a single dose, it can remain in the body for quite a few days and can cause the growth hormone to be released many times per day. This reduces the frequency of injections needed.
Dose-wise, studies have shown that the body will release a decent amount of natural GH with a dose of only 100mcg (termed the SATURATION DOSE) injected subcutaneously or intramuscularly. Higher doses can be used up to 300-500mcg in a single shot but double the dose does not mean double the GH; the amount of release is not directly proportional and the ratio of release diminishes as the dose climbs. I personally find 250mcg to be my sweet spot and doesn’t cost too much to run a short cycle at that dose.
CJC-1295 is a fast-acting Growth Hormone Releasing Hormone designed to enhance the body’s natural production and release of human growth hormone and Insulin-like Growth Factor 1 (IGF-1). In doing so, CJC-1295 reverses the age-related decline, generates new muscle cells and increases fat loss. Another great trait of CJC-1295 is its ability to promote slow wave sleep, a deep sleep responsible for the highest levels of cell regeneration, muscle growth and memory retention.
In June 2005, the NDPSC decided to reschedule pantoprazole from Schedule 4 to Schedule 3 when in oral preparations containing 20 mg or less of pantoprazole for the relief of heartburn and other symptoms of gastro-oesophageal reflux disease (GORD), in packs containing not more than 14 days' supply. This decision was based on the available efficacy and safety data which supported a Schedule 3 entry.

However, both the original GRF (1-29) and the Mod GRF 1-29 required frequent dosages. So a new compound called CJC-1295 was created which was far more stable. This compound was made by adding Lysine – which is a non-peptide, and is also called Drug Affinity Complex or DAC. Since the original Mod GRF 1-29 does not contain DAC, it is named as CJC-1295 without DAC. However, the actual CJC-1295 is not only difficult, but also very expensive to produce. This is why it is not produced or used extensively. The Mod GRF 1-29 is far easier and cheaper to produce.
Unlike GHRP 6, the Half Life of GHRP 2 is pretty short. In fact, GHRP 2’s peak can be seen occurring within fifteen minutes after it has been administered or at least one hour at the latest. Also unlike GHRP 6, GHRP 2 helps improve the levels of calcium in the body and this can in turn facilitate the secretion of other growth hormones. GHRP 2 is believed to be more potent in its operation as compared to other peptide forms, including GHRP 6. Therefore, it is not surprising to see this peptide commonly employed for treating catabolic deficiencies.
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