A SARM (an acronym for "Selective Androgen Receptor Modulator") is a drug that is chemically similar to anabolic steroids but with reduced androgenic properties. The main advantages SARMs have over anabolic steroids are androgen-receptor specificity, tissue selectivity, and reduced side effects. SARMs also have the ability to differentiate between anabolic and androgenic activities, whereas steroids do not.

For increasing GH levels, GHRP-6 is less effective in the presence of high blood glucose levels or high somatostatin levels, which result from high IGF-1 levels. For this reason, for best effect GHRP-6 should be taken while blood sugar is relatively low, for example about 30-60 minutes before a meal. GHRP-6 will have reduced effect if GH is being taken by injection, because GH increases IGF-1. Where GH use is limited to no more than about 14 IU per week, simultaneous GHRP-6 use probably still will increase GH somewhat further, but if GH use is greater than this then likely GHRP-6 injections will do little to nothing towards increasing GH levels any further.


The qualitative microscopic analysis of the GHRP-6 responsive wounds indicated that the peptide seems to primarily reduce both local hypercellularity associated with the cartilage perichondrium cells and the resulting ECM accumulation (Figures 6(a) and 6(b)). Accordingly, their SEI () appeared largely different () as compared to the placebo samples group (). It is notorious, however, that those GHRP-6 nonresponsive wounds () that evolved to HTS exhibited similar microscopic appearance (not shown) and SEI values as compared to placebo control wounds (Table 3).


Because the ligands of most GPCRs are unknown, assays for their activity generally have no positive controls. GHS-R, however, was known to bind several artificial ligands, such as GHRP-6 or hexarelin, providing a convenient positive control for constructing the assay system used to search for the endogenous ligand. A cultured cell line expressing the GHS-R was established and used to identify tissue extracts that could stimulate the GHS-R, as monitored by increases in intracellular Ca2+ levels. After screening several tissues, very strong activity by an endogenous ligand was unexpectedly found in stomach extracts (). The ligand was finally purified by reversed-phase HPLC (RP-HPLC) and named as ghrelin. The name “ghrelin” is based on “ghre,” a word root in Proto-Indo-European languages for “grow,” in reference to its ability to stimulate GH release. Ghrelin is a 28 amino acid peptide in which the serine 3 (Ser3) is n-octanoylated and this modification is essential for the activity of ghrelin (Fig. 2). Ghrelin is the first known case of a peptide hormone modified by a fatty acid. Rat and human ghrelins differ in only two amino acid residues. There is no structural homology between ghrelin and peptide GHSs such as GHRP-6 or hexarelin.
CJC1295 is a 30 amino acid peptide, which primarily functions as a growth hormone releasing hormone analogue (mimicking the effect of GHRH). It was initially invented to treat deep fat deposits in people, because it is known that having an increase in our own growth hormone levels will target this. It stimulates production of our own growth hormone from the pituitary gland.
I have not used IGF-1 but I have used a stack of Ipamorelin and CJC 1295 no DAC. I did not do any lab tests before, during or after but definitely noticed increased fat loss and better sleep. I was not trying to increase muscle so there was no change to speak of for me. But you are not recommending their use even without IGF-1, is that correct? I do not compete in anything so WADA is not a concern.
Boasting similar structure as CJC-1295, sermorelin is commonly used for anti-aging purposes. But it is also considered useful for muscle building. It accounts for 29 amino acids of the 44 that make up growth hormone releasing hormones. This peptide is very potent for improving HGH levels, as shown in studies. It was observed that the 1-29 amino acid chain is mainly responsible for the ability of GHRH to stimulate release of growth hormone by the pituitary. However, sermorelin has very short half-life of about 10 minutes or less.
It has been previously explained that some individuals will elect to administer GHRP-6 doses twice daily, and some more than three times daily. Twice daily administration of at least 100mcg (typically upon awaking and before sleeping) will yield anti-aging and general health benefits. 3 times daily administration should yield general health benefits, fat loss, and muscle gain. 4 times daily or greater administration should provide more pronounced muscle gains and fat loss.
IGF-1 is so named because of its close resemblance to insulin. Because IGF-1 is so similar to insulin, it interacts with insulin receptors on the surface of your cells, produces some of the same effects as insulin and even magnifies the effect of insulin. For example, one primary effect of both excess insulin and excess IGF-1 is hypoglycemia (low blood glucose). When you workout for a long time (longer than about one hour) your liver increases its release of IGF-binding protein (IGFBP-3) to prevent the onset of hypoglycemia that would otherwise happen as a result of the increased release of IGF-1 that occurs during training.
Another very positive benefit of CJC1295 is its ability to promote slow wave sleep. Slow wave sleep (SWS) is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS is decreased significantly in older adults and also with people who tend to exercise later in the evening.  This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.
Hexarelin via CD36 occupation increases the expression of multiple genes involved in fatty acid mobilization in adipocytes toward the mitochondrial oxidative phosphorylation, and many of these upregulated genes are known targets of PPARγ. Consistent with this, electron microscopy of hexarelin-treated adipocytes reflects highly organized cristae formation that spans the entire width of mitochondria, with a concomitant cytochrome c oxidase activity enhancement. Although this signaling and activation cascade has not been described for myocardial cells so far, the potential existence of these phosphorylative and mitochondriogenic mechanisms in the heart, and its potential amplification by GHRP ligands, may eventually contribute to myocardial salvage during critical ischemia periods.47 In a more recent study based on a myocardial infarction model, and addressed to examine whether hexarelin treatment can compensate for ghrelin deficiency in ghrelin-knockout mice, the mortality within two weeks was significantly lower in the hexarelin (6.7%) and ghrelin groups (14.3%) than in the vehicle group (50%). Furthermore, hexarelin was more effective than ghrelin as judged by the ejection fraction and other LV-dependent physiological constants as dP/dt max and dP/dt min, which is a measure of LV global contractility.48
Results: After a single injection of CJC 1295, there were dose dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9–11 d. The estimated half-life of CJC 1295 was 5.8–8.1 d. After multiple CJC 1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.

When using any GHRH, it should always be remembered that positive results cannot be achieved overnight. These compounds act steadily over time, and the best results can be achieved slowly, and with a nutritious diet and a proper exercise regime. Also, these peptides are not sex-specific, so they do not have any androgenic effects. They can be used by women in the same dosages that men do.
On this page: 1. Scheduling proposals referred to the October 2012 meeting of the Advisory Committee on Chemicals Scheduling (ACCS#6) | 2. Scheduling proposals referred to the October 2012 meeting of the Advisory Committee on Medicines Scheduling (ACMS#7) | 3. Scheduling proposals referred to the October 2012 joint meeting of the Advisory Committee on Chemicals Scheduling and Advisory Committee on Medicines Scheduling (ACCS-ACMS#4)
I started taking Ipamorelin and CJC 1295 without DAC yesterday. I dont see many logs and i see a lot of people wondering what kind of results you can get wiith these peptides. I have enough to go a couple of months right now and see what this stuff is really about. Im taking each 3x a day. Morning, pwo, and before bed. Im taking 100mcgs of each in the morning and before bed. After my workout, I'll take 100mcgs of cjc and 100-200mcgs of Ipa.
Technically, it is a “protein-peptide hormone” which means that it consists of 70 amino acids bonded together. Just like the peptides I’ve written about in the past, this means that it must be injected, because otherwise IGF-1 simply degrades in the gut, rendering it useless. Your own human growth hormone release promotes the synthesis of IGF-1 in your liver (and to smaller amounts, synthesis of IGF-1 by your muscles), your liver and muscles then synthesize IGF-1 and then, in the case of your liver, subsequently package the IGF-1 with binding proteins for transport into the blood. In a type of anabolic positive-feedback loop, IGF-1 then further increases growth hormone’s anabolic effects.

GHRP-6 and all GHRP’s are mimetics of ghrelin, a hormone produced by cells of the stomach in response to a fasted condition, including brief fasts. Ghrelin and ghrelin mimetics work by activating the ghrelin receptor, also called the growth hormone secretagogue receptor (GHS-R1a). Elevated ghrelin levels act towards increasing GH levels by stimulation of ghrelin receptors in the pituitary.


Boasting similar structure as CJC-1295, sermorelin is commonly used for anti-aging purposes. But it is also considered useful for muscle building. It accounts for 29 amino acids of the 44 that make up growth hormone releasing hormones. This peptide is very potent for improving HGH levels, as shown in studies. It was observed that the 1-29 amino acid chain is mainly responsible for the ability of GHRH to stimulate release of growth hormone by the pituitary. However, sermorelin has very short half-life of about 10 minutes or less.
The goal of this review is to offer a summary of the most relevant achievements of the pharmacological knowledge with synthetic GHRP (GHRP-6, GHRP-2, and hexarelin) in a historical perspective line. General cyto- and cardioprotection fields are specially focused, since all these agents have contributed to the discovery of novel functions and mechanisms involved in cellular survival, senescence, and death. We deem that cardiologists, clinicians, and basic and clinical pharmacologists would receive some benefit from this text, in correspondence to the futuristic pharmacological opportunities offered by these agents. To date, cytoprotection remains as an orphan niche in contemporary medical armamentarium.
Growth Hormone Releasing Peptide-6 is responsible for releasing growth hormone in appropriate quantities in the body and it does so by stimulating the pituitary gland. So what are the benefits of this hormone secretion process? Your body composition is likely to improve substantially once the GHRP 6 starts doing its work of secreting growth hormone. As a result of all this, individuals who are striving hard to get the body they are after will achieve their objective in a quick time and will also feel a lot better on the whole.
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