ADV Research ADV-11 (YK-11 SARM Alternative) All orders will be dispatched on Friday June 15th. KEY BENEFITS Powerful experimental myostatin inhibitor Potentially promotes lean muscle growth and increase lean body mass Potentially helps build on your genetic potential Potentially stimulates hair regrowth Potentially no negative impact on prostate size GENDER SUITABILITY ADV-11 may be suitable for use by both males…
One common concern when it comes to GHRP-6 doses (or the doses of any Ghrelin mimetic/GHRP) is the fact that it has been found to exhibit the ability to induce secretion of Cortisol and Prolactin. While many studies have indeed demonstrated this, they have also demonstrated that the Prolactin and Cortisol increases in most test subjects were not altered at all at GHRP-6 doses of 100mcg or less . GHRP-6 doses that are increased above 100mcg will exhibit increased Cortisol and Prolactin secretion, but minimally. As the dose is further increased, it stands to reason that the Cortisol and Prolactin secretions will increase as well.
A seminal report by a Merck Research Laboratories group dated 2003 demonstrated for the first time that chronic treatment with GHRP-6 (21 days) prevented sudden death in a canine model of DCM and subsequently subjected to acute myocardial infarction (AMI). In the meantime, the mortality rates for the vehicle and GH-treated groups were about 50%. Although the authors do not precise the mechanism underlying the 100% survival in the GHRP-6 group, an enhanced regional myocardial compensatory function of the nonischemic zone was assumed.40 This notion could be validated at least in part by the fact that the cardiotropic effects shown by GHRP-1, GHRP-2, GHRP-6, and hexarelin in cardiomyocytes and isolated, denervated, perfused hearts are mediated by an elevation of Ca2+ influx through the voltage-gated calcium channel, triggering Ca2+ release from thapsigargin-sensitive intracellular stores, which translated in a positive inotropic response without a chronotropic effect.41 More recent data confirm the ability of hexarelin and other secretagogue peptides that bind and activate the GHS-R1a, to control the cardiac action potential and reduce apoptosis of cardiomyocytes, derived from isolated hearts subjected to ischemia/reperfusion episodes.42
One of the other uses for GHRP-6 is to kick start your own GH after a cycle, a dose of 200-500mcg 2x a day is sufficient to start your own GH; however, it does not mean your own GH levels will be where they were before you carried out your cycle, this is user dependent. It will certainly be a very useful addition to any hormonal cycles' PCT, as the increased IGF-1 levels it brings will greatly increase the chances of you holding on to any muscle you have gained.
But for maintenance of adequate and natural IGF-1 and growth hormone, and to achieve that sweet spot of not becoming to pro-growth while also not becoming a weak, muscle-less noodle, that sweet spot of producing adequate insulin without producing too much, and that sweet spot of increasing cellular repair without letting cellular division get “out of control”, I have indeed been implementing three specific strategies: my IGF-1 “trilogy”.
Light-headedness and dizziness: GHRP-6 might commonly cause what is commonly referred to as a “head rush” feeling accompanied by a tingling and “pins and needles” feeling in the extremities, as reported by many users. This can also present itself as a spell of dizziness and/or light-headedness. It is in fact a strong indication that the hormone is indeed stimulating the pituitary gland, and is a side effect indicative of almost all HGH secretagogues.
Phenylephrine is readily eliminated by sulphate conjugation in the intestinal wall, and oxidative deamination by monoamine oxidative glucuronidation in the liver. Monoamine oxidase (MAO) inhibitors can enhance the limited potential of phenylephrine for cardiac and pressor effects, by reducing metabolism. As a largely specific alpha adrenergic drug, with very weak beta agonism, there is little direct cardiac effect. However, in higher doses, there can be increases in both systolic and diastolic blood pressure and a reflex bradycardia. As an adrenergic agonist there is the potential to interact with other sympathomimetic drugs. In overdose phenylephrine can cause hypertension, headaches seizures tachycardia, and vomiting. There has been no evidence from carcinogenicity studies in rodents of any enhanced cancer risk over prolonged exposure.
Total RNA was purified according to TRI Reagent standard procedure (Sigma, USA), following digestion with RQ1 DNase I (Promega, USA) to remove contaminating genomic DNA. Afterward, 500 ng of DNA-free RNA was reverse transcribed using Omniscript RT kit (Qiagen, Germany) with oligo-dT primer. The RT reaction was performed at 42°C for 60 min. PCR mixtures contained 1 μL cDNA, 1 μL of each primer (10 μM), and 12.5 μL 2x Taq MasterMix (Qiagen, Germany) in a final volume of 25 μL. Specific sense and antisense primers, annealing temperatures, and number of repeating cycles for both studies are referred to in Table 1. Amplifying conditions were performed as follows: a first step of 95°C for 5 minutes, thereafter repeating cycles comprised of 95°C for 30 seconds, specific annealing temperature for 30 seconds and 72°C for 30 seconds, and a final extension step of 5 minutes at 72°C. PCR bands (8 μL of PCR product plus 2 μL of gel loading buffer) were resolved on 1.5% (w/v) agarose gel electrophoresis and visualized under ultraviolet light subsequent to being stained with ethidium bromide. PCR products were quantified using the Kodak ID 3.6 software package (Kodak Inc, USA). Beta-2 microglobulin was used as housekeeping gene for normalization.
This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.
This is the most popular variant of IGF-1 that buyers will find on the market today. IGF-1 LR3 comprises 83 amino acids. That means it adds extra 13 amino acids to the sequence of the standard insulin-like growth factor-1. The polypeptide boasts qualities that make it much more powerful than normal IGF-1. It boasts a longer half life of up to 30 hours, compared to the latter’s 15 hours. In addition to bodybuilding, IGF-1 LR3 helps with fat burning, quicker recovery and slowing aging.
For example, insufficient protein or calories can cause IGF-1 to plummet, while ample calories can cause IGF-1 to increase. For example, one study of women who fed with excess calories over and above their normal metabolic rate noted a 19% increase in IGF-1 after two weeks of overfeeding, with 46% of the weight gain from lean mass and 54% from bodyfat. Fasting insulin doubled in these women, and testosterone levels also significantly increased.
Ipamorelin is a man-made peptide that is part of the growth hormone family. Rated as one of the safest in the peptide industry, it has strong growth hormone releasing properties. From this, it is a huge winner with athletes and bodybuilders. This is because it builds muscle and keeps weight down quickly. It works by sending signals to the pituitary gland at the base of the brain and adjusts and controls various body functions through the endocrine system. It binds certain receptors inside cells. This allows cells to respond and change, encouraging growth and regulation of hormones. Ipamorelin can help with:
Intestinal Growth: A potential problem often mentioned in association with IGF-1, however the large distended stomachs seen on professional bodybuilders are generally a result of over-dosing on Human Growth Hormone (HGH) rather than the usage of IGF-1. No anecdotal reports have been made by users of IGF-1 LR3 relating to growth of the gut so it is of little concern. Please ensure that you stick to our recommended doses and you will not have any issues.
When dosing, an appropriate volume will be drawn from the vial with (typically) an insulin syringe, according to the desired dose and the concentration of the preparation. In the above example, a 100 mcg dose would require only 0.05 mL, or “5 IU” as marked on an insulin syringe. A 300 mcg would require 0.15 mL, or “15 IU” as marked on an insulin syringe.
GHRP-6 is normally always manufactured as lyophilized (freeze-dried) powder contained in vials in amounts of 5mg. Some companies might manufacture amounts greater or lesser than 5mg per vial, but the standard is generally 5mg/vial. The lyophilized powder contained within the vial will need to be reconstituted with bacteriostatic water in order for it to be injected. After reconstitution, the solution must then be refrigerated in storage. If left in hot environments or in room temperature environments for extended periods of time, the protein structure will degrade and become ineffective. For reconstitution, users will typically mix 3ml of bacteriostatic water with the powder gently. However, users can and do frequently reconstitute the powder with less (or more) water which will yield different concentrations of GHRP-6. For example, reconstitution of 5mg of powder with 3ml of water will yield GHRP-6 doses of 166mcg per 0.1ml (or 10iu on an insulin syringe).
Conclusions: Subcutaneous administration of CJC 1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 ug/ kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC 1295 as a therapeutic agent.
"In circumstances where a medicine is widely known to be used in connection with modifying a physiological process in persons (as appears to be the case with some SARMs and other peptide products), that medicine is likely to satisfy the definition of a therapeutic good despite any disclaimer to the effect that it is for research purposes only and/or not for human use."
Molly Hunsinger is a communications professional and certified group exercise instructor and fitness trainer. Her medical, health and fitness industry background spans nearly three decades with experience working as an instructor trainer, staff trainer, facility manager, group exercise program manager, physician relations manager and marketing director. As a media professional, she has developed and launched award-winning allied marketing and advertising campaigns for luxury retailers, leading nonprofit organizations and foundations and written numerous articles and blogs for both digital and print publications. Molly holds a bachelor’s degree in mass communications from the University of South Florida with a concentration in journalism and digital media studies.
200 to 300 mcg is typically the daily dosage which is recommended for the typical Ipamorelin user. It can be taken anytime during the day but is advisable to be used in the morning, as it will help you achieve the best results in such cases. Regardless of when you start your dosage, it is important to ensure you are taking it at the same time each day. And, for new users, it is best to stick to a one-a-day cycle.
The consumption of such altered compounds may have severe consequences on the user's body and it is critical that they avoid such scenarios. The authorities need to grab the perpetrators responsible for the peddling of these illegal drugs in the market and regulate the black market. Given the many advantages this drug has for the human body and its potential as the all-round supplement, the authorities need to encourage the research and development agencies working on this drugs development. The emphasis should be on making it safer, more side-effect friendly and more compatible to mixing with other anabolic steroids.
I have not used IGF-1 but I have used a stack of Ipamorelin and CJC 1295 no DAC. I did not do any lab tests before, during or after but definitely noticed increased fat loss and better sleep. I was not trying to increase muscle so there was no change to speak of for me. But you are not recommending their use even without IGF-1, is that correct? I do not compete in anything so WADA is not a concern.
Peptides can make the goal of growing bigger muscles possible. They may also help to burn body fat, improve muscle recovery and slow aging. Each type has specific purposes for which it is more useful. These compounds are in many cases beneficial because of how they boost release of growth hormone by the pituitary gland. GH secretion is amplified when GHRH and GHRP substances are used together. As awesome as the benefits they offer sound, you should remember that peptides can be legally used for research purpose only.