Finally, the ghrelin chemical isolation and identification was accomplished surprisingly from the stomach, which is the major site but not the only site. Ghrelin was isolated and identified.4 A primary action of GHRPs continues to concern GH secretion and regulation, but increasingly this has included direct and indirect effects on nutrition and metabolism, as well as a variety of other actions which may be pharmacological and/or physiological.
The increase in GH secretion due to IPAMORELIN (and other GHRP) leads to an increase in IGF-1 (thought to be the anabolic mechanism of GH).  As we get older GH and subsequently IGF-1 decrease substantially.  This decline is thought to be one of the major causes of the ageing process.  By increasing these levels again there is increased collagen synthesis, promotion of lean muscle mass, bone strength, improved healing capability, improved sleep cycle, increased energy, repair and regeneration of internal organs, strengthening of joints/cartilage/connective tissue, and anti ageing effects on the skin. 
The two peptides CJC 1295 Ipamorelin, are often used in conjunction for better results. Known individually as CJC 1295 and Ipamorelin, these peptides have similar roles, which we will look at later. But for now, the CJC 1295 and Ipamorelin combination, is chiefly used together because the production of growth hormone secretion is 10 times more effective than using them individually. This makes it convenient for most users, to guarantee quicker results. Above all, it is popular among athletes, bodybuilders and weightlifters in need of building strength or speeding up the recovery of an injury.
Another very positive benefit of CJC1295 is its ability to promote slow wave sleep. Slow wave sleep (SWS) is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS is decreased significantly in older adults and also with people who tend to exercise later in the evening.  This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.
This class of peptides is used to enhance the insulin-like growth of muscles by bodybuilders. These compounds are great for targeting specific muscle groups. Also known as Somatomedic C, IGF-1 has become one of the more popular peptides used for muscle building in the last 10 years or so. Englishman Dorian Yates, who was named Mr. Olympian for six straight years in the 1990s, is thought to have been a prominent user. This contributed to make many professional bodybuilders to include it in their regimen as well. IGF-1 is also available in different variants.
Technically, it is a “protein-peptide hormone” which means that it consists of 70 amino acids bonded together. Just like the peptides I’ve written about in the past, this means that it must be injected, because otherwise IGF-1 simply degrades in the gut, rendering it useless. Your own human growth hormone release promotes the synthesis of IGF-1 in your liver (and to smaller amounts, synthesis of IGF-1 by your muscles), your liver and muscles then synthesize IGF-1 and then, in the case of your liver, subsequently package the IGF-1 with binding proteins for transport into the blood. In a type of anabolic positive-feedback loop, IGF-1 then further increases growth hormone’s anabolic effects.
Well, personally I used 150mcg injected directly into the joints or areas that I've had any niggling injuries, the localized effect it has on collagen growth is nothing short of astounding. After using GHRP-6, I have personally recovered from a full pectoral tendon tear, where the tendon ripped right of the humerus bone; in fact, it's now in better shape than it was prior to the injury. Interestingly, 5g of the GHRP-6 will last ages when used properly; even at this dose fat loss is noticeable and the anabolic effects of increased muscle size and strength can be seen.

Thymosin alpha-1 (T α 1) is a peptide, or small protein, consisting of 28 amino acids. T α 1 is produced naturally by the thymus gland. The thymus is located behind the sternum and between the lungs, and is where immune cells known as T cells mature and are released, prompted to do so by the T α 1 peptide. T cell production and action within the body is vital to adaptive immunity—the mode by which immune cells are able to recognize and eradicate foreign invaders.
Just as the name suggests, GHRH helps to stimulate secretion of growth hormone. The duration of secretion induced will depend on the specific type of peptide that you use. An important thing to note here is that these substances are effective only to a limit. Exceeding the saturation dose, which may vary between individuals, will not improve the amount of HGH that is secreted. Below are a few peptides that fall in the GHRH group.

Increasing HGH release levels in your body naturally. It sounds too good to be true, but what if you could achieve just that by using a supplement? Using Ipamorelin alongside your exercise and diet regimen is going to help you achieve said goal. No two users are alike. For athletes or those who workout religiously, you might experience greater results than an individual who is overweight and just getting back into the gym after 10 years. So, take it with a grain of salt when detailing the results below. Dosage, your body composition, and other factors will play a role in the results you can expect to see when you incorporate Ipamorelin.
Two submissions were received, both in relation to AOD-9604. One submission did not comment on the scheduling proposal, but wished to inform the committee that the substance is an ingredient in cosmetic products being sold overseas, has an International Nomenclature Cosmetic Ingredient (INCI) name of 27701 sh-Oligopeptide-74 and is published in the International Cosmetic Ingredient Dictionary and Handbook as well as the International Buyer's Guide.
GHRP-6 is normally always manufactured as lyophilized (freeze-dried) powder contained in vials in amounts of 5mg. Some companies might manufacture amounts greater or lesser than 5mg per vial, but the standard is generally 5mg/vial. The lyophilized powder contained within the vial will need to be reconstituted with bacteriostatic water in order for it to be injected. After reconstitution, the solution must then be refrigerated in storage. If left in hot environments or in room temperature environments for extended periods of time, the protein structure will degrade and become ineffective. For reconstitution, users will typically mix 3ml of bacteriostatic water with the powder gently. However, users can and do frequently reconstitute the powder with less (or more) water which will yield different concentrations of GHRP-6. For example, reconstitution of 5mg of powder with 3ml of water will yield GHRP-6 doses of 166mcg per 0.1ml (or 10iu on an insulin syringe).
This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.
Now, you may have heard many bodybuilders saying that when you take GHRP-6 that they get a huge and very intense increase in appetite, about 20 mins after the initial injection. Well, this is caused by the GHRP-6 antagonising the peptide Ghrelin, it mimics it, but, in reality, it actually fights against it causing the signal for gastric emptying and hunger. Ghrelin is what many believes causes obesity, and insulin resistance amongst other things, and I believe this is one way by which GHRP-6 may help reduce fat, by fighting against it. However, there is always a but, if you take more than 150mcg the effects of the gastric emptying can be so strong that you may have the urge to severely stuff yourself with food, so if you're on a bulking cycle this is a great side effect, and, considering the price, it's a very cost-effective one. Therefore, during a bulking run, I rate this as the number one aid in increasing appetite, as you also get very a good anabolic effect and increased strength.
By increasing our own growth hormone levels (which normally decrease as we age), there is an increase in protein synthesis which subsequently stimulates muscle growth.  It leads to an increase in muscle mass, an increase in fat metabolism (fat loss), and increase in physical strength.  It is also helpful in skin ageing, and effective in reducing wrinkles.
Depending on the intended use, and your desired results, the dosage levels are going to vary from person to person as well. So, keep this in mind when trying to determine how great the results are actually going to be when you are using Ipamorelin. So, what exactly can you expect when using this supplement? Some things you will see, for every user is:
In March 1972, the Drugs and Poisons Schedule Subcommittee (DPSSC) decided to include vitamin D in Schedule 4 when the recommended daily dosage on the label exceeds 10 micrograms. This recommendation was based on a recommendation by the Nutrition Committee of the National Health & Medical Research Council that the attention of pharmaceutical firms be drawn to the dangers of vitamin A overdose.
GHRH/GHRP-6 was the first of a family of synthetic peptides that enhance the release of the GH by the pituitary gland in a dose-dependent manner. Since its discovery, it has been used as a benchmark and starting point for many of the research aims to obtain new drugs, but none of its implications are more engaging than the treating of the obesity epidemic.

Yes, Ipamorelin can help you lose weight. But, if you are not exercising, and aren’t eating well, it can only do so much. There is no magical supplement which will undo laziness and a horrible diet – keep this in mind. When using it for fat loss, make sure you are exercising. Doing so will naturally increase weight loss results, as you are going to burn more calories, along with the caloric deficit you are already on, for greater results. Further, your diet matters. If you are eating 5000 calories of junk per day, no supplement will help you lose weight – no matter how potent it claims to be!

CJC1295 is a 30 amino acid peptide, which primarily functions as a growth hormone releasing hormone analogue (mimicing the effect of GHRH).  It was initially invented to treat deep fat deposits in people, because it is known that having an increase in our own growth hormone levels will target this.It stimulates production of our own growth hormone from the pituitary gland.  
Obviously, Increasing GH (and therefore IGF-1) levels are desirable for those looking to improve their physique in terms of increased muscle mass and loss of body fat, rejuvenation and strengthening of joints through connective tissue synthesis and bone mass density increases, as well as enhancing immune response and stimulating the immune system, particularly in those of us getting on in years (ahem). For anti-ageing purposes, GHRP-6 is normally singly dosed just before bed at night with users reporting the best night’s sleep they have ever had plus some funky dreams to match (since GH is released during REM or ‘dream sleep’ so the GHRP-6 sort of ‘forces’ us to dream). For bodybuilding purposes, users attempt to mimic pulsatile GH release for best results by administering multiple times throughout the day.
Intestinal Growth: A potential problem often mentioned in association with IGF-1, however the large distended stomachs seen on professional bodybuilders are generally a result of over-dosing on Human Growth Hormone (HGH) rather than the usage of IGF-1. No anecdotal reports have been made by users of IGF-1 LR3 relating to growth of the gut so it is of little concern. Please ensure that you stick to our recommended doses and you will not have any issues.

The response of these wounds reminds us of the pattern of healing described for MG53 protein (a membrane repair machinery member), so that the treatment facilitated wound healing along with a reduced scarring in rodent models. This antiscar effect was explained by interfering with TGF-β-dependent activation of myofibroblasts differentiation and reduction of ECM proteins accumulation [22]. Similarly, antiscarring healing properties are described for plants’ principles that downregulate the expression of fibrogenic-related molecules such as TGF-β1 and the downstream events, leading to fibrosis and scar formation [23]. In addition to a direct action of GHRP-6 on TGFB1 gene expression, we deem that the reduction of inflammatory effectors could have also contributed to enhancing the healing process and to reducing fibrosis. In an animal model of liver ischemia/reperfusion, we previously demonstrated that GHRP-6 prevented internal organs parenchymal activation and the onset of a systemic inflammatory response syndrome by downregulating proinflammatory cytokines [24]. Subsequent studies have demonstrated the ability of different GHRPs to ameliorate local and systemic inflammatory processes in a variety of experimental scenarios by suppressing the activation of NF-κB, the consequent expression of proinflammatory cytokines, and acting as chemokine receptor antagonist [25–27]. Differentiation to myofibroblasts, collagen fibrillogenesis, and matrix accumulation are controlled by opposing forces: proinflammatory and profibrogenic, that require a fine tuning to ensure a proper esthetic healing and effective mechanical properties of the ECM [28, 29]. The overall interpretation of the data from (i) the rate of closure, (ii) microscopic appearance of the collagen fibrils alignment/organization, (iii) impact of the treatment on the transcriptional expression of cytoskeleton filamentous proteins (smooth muscle α-actin (α-SMA), desmin, and vimentin) supports the hypothesis that, in this context, GHRP-6 has shifted the balance toward “a more regenerative” rather than a reparative phenotype.

As an extra note, there are a few things that should be mentioned about increased prolactin and cortisol levels when using certain peptides. My experience is with even high and frequent doses cortisol was raised but nothing to be alarmed about. Also, some peptides are sensitive to foods interfering with the peptides ability to take effect. Therefore, a safe rule of thumb is to not eat 30 minutes before and after dosing to make sure that no foods are facilitating the breakdown of these peptide chains upon subcutaneous or intramuscular injection.

In studies GHRP-6 has shown biological actions similar to the naturally occurring hunger stimulating peptide ghrelin. Its main use is to promote food intake by stimulating hunger and aid in energy metabolism. It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity. GHRP-6 is a synthetic met-enkephalin (a naturally occurring opioid growth factor) analog. GHRP-6 contains D-amino acids that are entirely synthetic, lacks opioid activity, and shares no sequence relation with GHRH. It has also been shown that GHRP-6 can lead to re-stimulation of the natural production of HGH.
Our first human GHRP-6 studies in normal young men were performed in collaboration with Michael Thorner (Bowers et al., 1990). These studies (Fig. 1.7, left panel) revealed that iv bolus GHRP-6 released GH and, when given together with GHRH, released GH synergistically. One of the most characteristic and consistent in vivo actions of GHRPs in various animals as well as humans of both sexes and all ages is the synergistic release of GH when GHRP is administered concomitantly with GHRH by iv bolus. Subsequently, this was also found for continuous 24/7 subcutaneous (sc) infusion. Also recorded in Fig. 1.7, right panel, is the comparative GH-releasing effects of iv bolus GHRP-6, -1, -2, and GHRH in normal young men. The potency of the three GHRPs we developed over several years was increasingly effective in releasing GH, and each released more GH than GHRH in normal young men. In addition, this was also found to occur in normal young women (Bowers, 1996).
ADV Research ADV-17 Post Cycle Therapy PRODUCT STRENGTH (CONCENTRATION): 30MG/ML KEY BENEFITS Raises testosterone levels Lowers estrogen levels Raises luteinizing hormone (LH) levels Lowers cortisol levels Enhances recovery speed Promotes vascularity (hardening and drying out) Increases libido Inhibits gynecomastia (male breast enlargement) Promotes fat loss Not liver toxic GENDER SUITABILITY ADV-17 is suitable for use by males. Females should not…
When you are just getting started with Ipamorelin, it is advised to use only one supplement daily at the same time each day. It is also advised to begin on the lower end, typically an eight-week cycle, and at a maximum twelve-week cycle. Doing this not only guarantees the desired results when using Ipamorelin, it is also going to ensure you get the most out of the supplement. When using this dosage cycle you will:
Administration of peptides is normally subcutaneous or intramuscular. Peptides come as a fine white and delicate powder that must be reconstituted with bacteriostatic water or medical grade saline. An insulin syringe should always be used to administer the dose. When targeting muscles, look for a place where the layer of skin and fat are lean. Mixing two peptides in the same syringe is totally fine but I personally would advise not drawing/mixing doses and storing pins for future use.
Before the discovery of ghrelin, synthetic GH secretagogs were available. Several studies investigated the effects of these substances on human sleep. Oral administration of the GH secretagog MK-677 for 1 week prompts a distinct sleep-promoting effect in healthy young male volunteers, whereas a weak effect is observed in elderly subjects. This study shows that oral administration of a peptide is capable of promoting sleep. After repetitive intravenous administration of GH-releasing peptide 6 (GHRP-6), non-REM sleep stage 2 increases. Similar to the effects of ghrelin in male subjects GH, ACTH, and cortisol are elevated. In a set of studies, the intranasal, oral, and sublingual administration of GHRP-6 was tested. By these routes of administration the effects of the peptide on the sleep EEG and on hormone secretion are less distinct and partly different from those after intravenous injection. In contrast to the sleep-promoting effects of GHRP-6 and ghrelin, hexarelin prompts a decrease of SWS, whereas the pattern of endocrine effects after hexarelin resemble the endocrine changes after ghrelin and GHRP-6 in that there is a marked stimulation of GH. The decrease of SWS after hexarelin may be related to negative feedback inhibition of endogenous GHRH. After a single dose of GHRP-2 during the third period of REM sleep, sleep remains unchanged. The lack of effects in this study may be related to the method that uses only a single injection of the substance.
Since GHRP-6 influences natural GH release, rules for its administration are similar to those when administering GH itself, i.e. do not have the dose within a 2 hour window after a meal, and/or wait 30 minutes till eating after dosing, due to any endogenous insulin release from the meal possibly stunting the release of natural GH and its uptake by the relevant cells.

Unfortunately, as we age, the amount of growth hormone that is produced starts dropping, and into our 40’s it starts dropping off rapidly. This is where GHRP-6 can help a lot, as it mimics ghrelin in the body, which stimulates the ghrelin receptors. When this occurs, a signal is sent to the pituitary gland, increasing GH production. Another benefit of GHRP-6 is that it blocks out a hormone called somatostatin, which is the enemy of HGH secretion. Finally, there is evidence that GHRP-6 can have a positive effect on the nervous system by protecting neurons, giving the user a much higher overall wellness.
GHRH (Growth Hormone Releasing Hormones) cause the body to secrete a small amount of growth hormone. Depending upon the peptide, there can be short to long secreting times. Also, be aware that with most peptides there is a saturation dose (normally around 100mcg at a time). This means that going beyond the saturation dose will not produce an increase in growth hormone release. Experienced peptide users have indicated that saturation doses may actually be higher than 100mcg. However, this seems to depend on the purity of the peptides, and perhaps even based on the individual person themselves. In general, due to the nature of peptides, a lot of information has become anecdotal in nature rather than scientific.

Peptides: Are a small chain of amino acids that isn’t quite long enough to be considered a protein. In other words they are the building blocks for protein in the body. They actually have a wide range of functions with the most popular being an increase in growth hormone, increase in recovery (and by default muscle building) and even a natural tan.

GHRH (Growth Hormone Releasing Hormones) cause the body to secrete a small amount of growth hormone. Depending upon the peptide, there can be short to long secreting times. Also, be aware that with most peptides there is a saturation dose (normally around 100mcg at a time). This means that going beyond the saturation dose will not produce an increase in growth hormone release. Experienced peptide users have indicated that saturation doses may actually be higher than 100mcg. However, this seems to depend on the purity of the peptides, and perhaps even based on the individual person themselves. In general, due to the nature of peptides, a lot of information has become anecdotal in nature rather than scientific.
Dosing will ordinarily be at least twice per day and preferably 3x/day for best effect, taken at least 30-60 minutes before a meal and at a time of non-elevated blood sugar (in other words, after blood sugar has had time to fall since the most recent meal.) The amount taken generally will be from 50-300 mcg at a time. When using a GHRH along with GHRP-6, dosing should be reduced to 50-100 mcg at a time.

Unfortunately, as we age, the amount of growth hormone that is produced starts dropping, and into our 40’s it starts dropping off rapidly. This is where GHRP-6 can help a lot, as it mimics ghrelin in the body, which stimulates the ghrelin receptors. When this occurs, a signal is sent to the pituitary gland, increasing GH production. Another benefit of GHRP-6 is that it blocks out a hormone called somatostatin, which is the enemy of HGH secretion. Finally, there is evidence that GHRP-6 can have a positive effect on the nervous system by protecting neurons, giving the user a much higher overall wellness.

For example, there are Growth Hormone Releasing Peptides (GHRP’s with names such as ipamorelin and hexarein) which allow for a slow and steady growth hormone release that produces a pulse which mimics natural growth hormone release times and Growth Hormone Releasing Hormones (GHRH’s such as Mod-GRF) for an even stronger natural release of growth hormone and greater presence of growth hormone precursors known as GH “frags” or fragments.
In June 2011 the Advisory Committee on Medicines Scheduling was referred a proposal by the delegate to consider up-scheduling of five (5) then unscheduled substances contained in cold and cough preparations into Schedule 2. One of these substances was phenylephrine and many public submissions received rejected this proposal on the grounds of the paracetamol/phenylephrine exemptions in the Schedule 2 entry. The committee made similar comments and the delegate agreed that the current exempt from scheduling status of phenylephrine was appropriate.
Following the preliminary histological data, suggesting a reduction of wound inflammation and a far more organized ECM, we addressed the gene expression study toward inflammatory and profibrogenic markers. We primarily examined Cd36 expression following topical GHRP-6 application and found that peptide reduced its receptor expression () (Figure 4). Furthermore, the treatment significantly reduced Adam17 expression () and approached to significantly reduce Tnf (), which may partially contribute to explaining the substantial reduction of infiltrated inflammatory cells within the wound bed (Figure 4).
Results and expectations from an HGH secretagogue such as GHRP-6 should be all of the same effects that any other form of Human Growth Hormone would provide. This includes fat loss, muscle mass increases, strength gains, healing and repair of joints and connective tissue, and a plethora of other benefits and changes. An important note to make is that the effects from any HGH application, whether it be an endogenous release from a GHRH or synthetic HGH administration, will all occur rather steadily over a longer period of use. Dramatic results within weeks are never to be expected, but with proper nutrition and training, dramatic performance and physique changes should occur steadily over the course of several months of application. For more information on HGH specific results and expectations, please see the Human Growth Hormone profile.
"From the 1st click, my experience with Elite Sarms was great. My order was confirmed within seconds, packed & shipped that day, & delivered so quickly! Hyper Lean was my first sarms experience, & noticed an effect within a couple days. My diet has remained constant - food groups, cals, macro ratios - all the same - & have really leaned out in a short time! My body resisted change for months of dieting, carb cycling, & various training forms - up & down, & my constant stress levels didn't help at all. But with Hyper Lean I've found it does exactly what it says it does - metabolism is up as I drop fat & increase mass. I've had no negative side effects. And the strength - I find that the metabolism boost aids my recovery & my energy output, despite being in a slight caloric deficit I'm gaining muscle, and my previous PRs are history - after 6 months of struggles I feel like an athlete again! Thanks Elite Sarms - I'm impressed! " EP
A remarkable specific (125)I-Tyr-Ala-hexarelin binding was observed in the human cardiovascular system where the highest binding levels were detected in ventricles, followed by atria, aorta, coronaries, carotid, endocardium, and vena cava. In other experiments on H9c2, cardiomyocyte-specific GHRP binding was found along with a potent antiapoptotic activity.3 The primarily investigated receptor was the growth hormone secretagogue receptor type 1a (GHS-R1a), which was detected in isolated human cardiomyocytes, myocardium, and aorta samples.17 It has been recently shown that GHS-R1a is a sort of “promiscuous receptor” involved in many systems and behavioral patterns such as reward, feeding, and memory, which makes it an attractive pharmacological target.18 Years later, the synthetic GHRP hexarelin was acknowledged as a ligand of another protein identified as CD36, a scavenger receptor that is expressed in various tissues, including monocytes/macrophages and the endothelial microvasculature. Activation of CD36 in perfused hearts by hexarelin was shown to increase coronary perfusion pressure in a dose-dependent manner. Contrariwise, this effect was lacking in hearts from CD36-null mice and hearts from spontaneous hypertensive rats genetically deficient in CD36.19,20 Thus, it is currently accepted that two cardiac receptor subtypes mediate the pharmacological actions of GHRP-6, GHRP-2, and hexarelin.21,22